反应详情

温度

50 °C

The title compound was prepared by adding the 3-bromo-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile (15.20 g, 49.65 mmol), ethanol (130 mL), 30% hydrogen peroxide (aqueous) (130 mL), and 6 N sodium hydroxide (aqueous) (9 mL) to a 2 liter round bottom flask. This mixture was heated at 50° C. for 1 hour, and removed from the heat to allow to cool to room temperature. The pH was adjusted to ˜3 by adding 6 N hydrochloride solution (aqueous) resulting in a precipitate. This precipitate was filtered and washed with water (15.13 g, 94%): ES-MS (m/z) 324 [M+1]+.

1. customremoved from the
2. temperatureheat
3. temperatureto cool to room temperature
4. additionby adding 6 N hydrochloride solution (aqueous)
5. customresulting in a precipitate
6. filtrationThis precipitate was filtered
7. washwashed with water (15.13 g, 94%)