Indomethacin → HCID 178486287, compound

HRID 1273177Notes

Reaction equation

HRID 1273177 reaction equation
CNS(=O)(=O)Cc1ccc(N)cc1.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>C1CCOC1.CN(C)C(=[Cl+])N(C)C.Cn1ccnc1.F[P-](F)(F)(F)(F)F>CNS(=O)(=O)Cc1ccc(NC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 27781314-Amino-N-methylbenzenemethanesulfonamide

Product 1

HCID 178486287HCID 178486287, compoundYield 61.17%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 178483690HCID 178483690, compoundReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-e7f243fc848b4c83878cbe73900d603e
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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