Indomethacin → HCID 178486287, compound

HRID 1273196Notes

Reaction equation

HRID 1273196 reaction equation
CNS(=O)(=O)Cc1ccc(N)cc1.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>CC#N.CCN(C(C)C)C(C)C.CN(C)C(=[O+]n1nnc2cccnc21)N(C)C.F[P-](F)(F)(F)(F)F>CNS(=O)(=O)Cc1ccc(NC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 27781314-Amino-N-methylbenzenemethanesulfonamide

Product 1

HCID 178486287HCID 178486287, compoundYield 53.05%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)ReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-6270e5863d144e1686cb8a69b5787ee6
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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