HCID 58994227, compound → HCID 58994243, compound

HRID 12732Notes

Reaction equation

HRID 12732 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16](OC)[O:17]C)[CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:23])[N:3]=1>C1COCC1>[Cl:1][C:2]1[C:7]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16]=[O:17])[CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:23])[N:3]=1

Participants

3

Reactant 1

HCID 58994227HCID 58994227, compound

Product 1

HCID 58994243HCID 58994243, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(2-Chloro-6-methyl-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep108, 90 mg, 0.26 mmol) was dissolved in THF (4 ml) and 1N HClaq (265 μl) was added. The solution was then stirred at room temperature for one hour and then warmed at 40° C. for 2.5 hours. TEA (45 μl) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

Workup

  1. addition1N HClaq (265 μl) was added
  2. temperaturewarmed at 40° C. for 2.5 hours
  3. customthe solvent was carefully removed in vacuum at room temperature
  4. customdried
  5. customto give a white powder that
  6. customwas used in the next step without further purification (quantitative yield)

Sources & evidence

ORD record
ord-a71832c0ceba4f5ca3e69a526304511b
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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