Indomethacin → HCID 178487188, compound

HRID 1273485Notes

Reaction equation

HRID 1273485 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(Cl)c(N)c1>CN(C)C(=[O+]n1nnc2cccnc21)N(C)C.CN(C)C=O.Cn1ccnc1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1cc(C#N)ccc1Cl)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1044643-Amino-4-chlorobenzonitrile

Product 1

HCID 178487188HCID 178487188, compoundYield 7.35%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)ReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-e3f60987fd984df29ff1bba2c1f9924d
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…