HCID 58994249, compound → HCID 58994157, compound

HRID 12735Notes

Reaction equation

HRID 12735 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[CH3:18])[C:9](=[O:19])[NH:8][C:7]1=[O:20]>C1COCC1>[CH3:18][C:17]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:10]1[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=1

Participants

3

Reactant 1

HCID 58994249HCID 58994249, compound

Product 1

HCID 58994157HCID 58994157, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

1-(3,3-Dimethoxy-propyl)-5-(4-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione (Pre112, 100 mg, 0.32 mmol) was dissolved in THF (5 ml) and 1N HClaq (327 μl) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (45 μl) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give the title compound that was used in the next step without further purification (quantitative yield).

Workup

  1. addition1N HClaq (327 μl) was added
  2. customthe solvent was carefully removed in vacuum at room temperature
  3. customdried

Sources & evidence

ORD record
ord-ec7bd10461df43f8b74b205be880fb9b
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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