Indomethacin → HCID 178487188, compound

HRID 1273525Notes

Reaction equation

HRID 1273525 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(Cl)c(N)c1>C1CCOC1.Cn1ccnc1.O=P(Cl)(c1ccccc1)c1ccccc1>COc1ccc2c(c1)c(CC(=O)Nc1cc(C#N)ccc1Cl)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1044643-Amino-4-chlorobenzonitrile

Product 1

HCID 178487188HCID 178487188, compoundYield 7.26%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 73910Diphenylphosphinic chlorideReagentHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-5f1ceb3484c540ecb343b64bf99441d1
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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