Hydrochloric Acid → 5-(2-Fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12737Notes

Reaction equation

HRID 12737 reaction equation
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58994242HCID 58994242, compound

Product 1

HCID 686914385-(2-Fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochlorideYield 93%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5-(2-Fluoro-6-methyl-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep114, 691 mg, 2.76 mmol) was dissolved in 4M HCl in dioxane solution (7 ml). After refluxing the reaction mixture for 45 minutes, the solvent was removed under vacuum to give 667 mg of the title compound (93% yield)

Workup

  1. temperatureAfter refluxing the reaction mixture for 45 minutes
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-3fb63e5718eb421b975c24ab94c9dd0a
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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