Indomethacin → HCID 178487186, compound

HRID 1273914Notes

Reaction equation

HRID 1273914 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N=c1ccc(Cl)n[nH]1>CC#N.Cc1cccc(C)n1.O=P(Cl)(c1ccccc1)c1ccccc1>COc1ccc2c(c1)c(CC(=O)Nc1ccc(Cl)nn1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 178507598HCID 178507598, compound

Product 1

HCID 178487186HCID 178487186, compoundYield 23.49%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 73910Diphenylphosphinic chlorideReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-2d6841ac9c8b4e899dfa009de8cb4934
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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