Indomethacin → HCID 178498032, compound

HRID 1274012Notes

Reaction equation

HRID 1274012 reaction equation
COC(=O)c1ccc(Cl)cc1N.COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1>CC#N.CCN(C(C)C)C(C)C.O=P(Cl)(c1ccccc1)c1ccccc1>COC(=O)c1cc(Cl)ccc1NC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 80001Methyl 4-chloroanthranilate

Product 1

HCID 178498032HCID 178498032, compoundYield 3.73%

Reagents, catalysts & solvents 3

HCID 73910Diphenylphosphinic chlorideReagentHCID 81531DiisopropylethylamineReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-0d651513e94e4b4bace01600ab27ab01
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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