反应详情

温度

25 °C

A solution of (11) (0.009 g, 0.025 mmol) in HCl (5 mL, 4M in 1,4-dioxane) was capped with a drying tube and stirred at 25° C. for 12 h. The reaction mixture was evaporated to a pale yellow oily residue (0.009 g, quantitative yield); 1H NMR (DMSO) δ 8.42 (d, 2H, J=4.8), 7.67 (d, 2H, J=8.7), 6.70 (t, 1H, J=4.8), 6.67 (d, 2H, J=9.3), 4.54 (d, 2H, J=13.2), 3.72 (m, 1H), 3.20 (t, 2H, J=11.1), 1.98 (d, 2H, J=10.7), 1.34 (m, 2H); 13C NMR (CDCl3) δ 167.4, 158.9, 157.7, 151.0, 131.2, 117.4, 111.7, 109.7, 48.9, 43.6, 30.9; HRMS (FAB) m/z 299.1518 (M+H)+ (C16H18N4O2 requires 299.1508).