4-Benzyloxyaniline → HCID 70269237, compound

HRID 1274158Notes

Reaction equation

HRID 1274158 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[CH2:17]([O:24][C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:14][O:13][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[O:15][CH3:16])[N:3]=[C:2]([NH:29][C:28]1[CH:27]=[CH:26][C:25]([O:24][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[CH:31][CH:30]=1)[N:11]=[C:10]2[NH2:12]

Participants

3

Reactant 2

HCID 228604-BenzyloxyanilineHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

Product 1

HCID 70269237HCID 70269237, compound

Procedure

2-chloro-6,7-dimethoxy-4-quinazolinamine (1.73 g, 7 mmol) and 4-benzyloxyaniline (2.5 g, 12 mmol) were heated in an s.s. bomb at 145° C. for 16 hrs. Upon cooling the resultant solid was washed well with ether to afford the product. 1H NMR DMSO 3.86 (d, 6H , OCH3), 5.14 (s, 2H, CH2), 6.9-7.5 (m, 11H, ArH)

Workup

  1. temperatureUpon cooling the resultant solid
  2. washwas washed well with ether
  3. customto afford the product

Sources & evidence

ORD record
ord-044c75698b07478599b03a0ce5ac87a0
Source dataset
uspto-grants-2000_12
Patent number
US06156758

Reaction notes

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