Hydrochloric Acid → HCID 69823848, compound

HRID 1274171Notes

Reaction equation

HRID 1274171 reaction equation
C([NH:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])[CH3:6])(=O)C.[ClH:20]>>[ClH:20].[NH2:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[N+:17]([O-:19])=[O:18])[CH3:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12109159HCID 12109159, compound

Product 1

HCID 69823848HCID 69823848, compound

Procedure

Methyl (R)-4-(1-acetamidoethyl)-3-nitrobenzoate (650 mg) was dissolved in 2N hydrochloric acid, and the mixture was refluxed for 2 hours. After the reaction, the reaction mixture was evaporated under reduced pressure, and further boiled with toluene, which was followed by drying to give 620 mg of (R)-4-(1-aminoethyl)-3-nitrobenzoic acid hydrochloride.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customAfter the reaction
  3. customthe reaction mixture was evaporated under reduced pressure
  4. customby drying

Sources & evidence

ORD record
ord-d7de914f3d384321aa599b87df64c493
Source dataset
uspto-grants-2000_12
Patent number
US06156766

Reaction notes

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