Water → HCID 131722193, compound

HRID 1274198Notes

Reaction equation

HRID 1274198 reaction equation
S(OS(C(F)(F)F)(=O)=O)(C(F)(F)F)(=O)=O.COC1C=C(OC)C=CC=1C[N:27]([CH:52]1[CH2:54][CH:53]1[C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1)[C:28]1[C:29]2[N:40]=[N:39][N:38]([CH:41]3[CH:45]4[O:46]C(C)(C)[O:48][CH:44]4[CH:43](O)[CH2:42]3)[C:30]=2[N:31]=[C:32]([S:34][CH2:35][CH2:36][CH3:37])[N:33]=1.[N:61]1C=CC=CC=1.O.[Cl:68]CCl>>[ClH:68].[NH2:61][CH:43]1[CH2:42][CH:41]([N:38]2[C:30]3[N:31]=[C:32]([S:34][CH2:35][CH2:36][CH3:37])[N:33]=[C:28]([NH:27][CH:52]4[CH2:54][CH:53]4[C:55]4[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=4)[C:29]=3[N:40]=[N:39]2)[CH:45]([OH:46])[CH:44]1[OH:48]

Participants

6

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 6344DichloromethaneHCID 67749Trifluoromethanesulfonic anhydrideHCID 86757047HCID 86757047, compound

Product 1

HCID 131722193HCID 131722193, compound

Procedure

Triflic anhydride (0.08 ml) was added to a solution of the product from step (h) (147 mg) and pyridine (0.08 ml) in dichloromethane (2 ml) and stirred for 18 hours. Water was added and the mixture was extracted with dichloromethane. The organic layer was dried (MgSO4), evaporated and purified (SiO2, petrol:ether 3:2 as eluent) to give the sub-title compound as a white foam (166 mg).

Workup

  1. extractionthe mixture was extracted with dichloromethane
  2. dry with materialThe organic layer was dried (MgSO4)
  3. customevaporated
  4. custompurified (SiO2, petrol:ether 3:2 as eluent)

Sources & evidence

ORD record
ord-baae653aec654a1fb256da4bda0b0fa2
Source dataset
uspto-grants-2000_12
Patent number
US06156756

Reaction notes

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