HCID 58994161, compound → HCID 58994176, compound

HRID 12742Notes

Reaction equation

HRID 12742 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[N:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[C:9](=[O:18])[NH:8][C:7]1=[O:19]>C1COCC1>[O:19]=[C:7]1[NH:8][C:9](=[O:18])[C:10]([C:12]2[N:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:11][N:6]1[CH2:5][CH2:4][CH:3]=[O:2]

Participants

3

Reactant 1

HCID 58994161HCID 58994161, compound

Product 1

HCID 58994176HCID 58994176, compoundYield 110.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(3,3-Dimethoxy-propyl)-5-pyridazin-3-yl-1H-pyrimidine-2,4-dione (Prep122, 200 mg, 0.68 mmol) was dissolved in THF (5 ml) and then 2N HClaq (1 ml) was added. The solution was stirred at room temperature for 1 hour. The solvent was removed under vacuum at room temperature and the residue was lyophilized to give 185 mg of the title compound as hydrochloride salt (95% yield).

Workup

  1. addition2N HClaq (1 ml) was added
  2. customThe solvent was removed under vacuum at room temperature

Sources & evidence

ORD record
ord-f76a2bda0a47446a84dc131be67e5ed1
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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