反应详情

To a solution of p-fluorothiobenzamide (0.39 g, 2.5 mmol) in 20 ml of abs. EtOH is added 2,4'-dibromoacetophenone (0.7 g, 2.5 mmol) all at once. The reaction mixture is stirred at room temperature for 3 hours and then chilled in ice bath. The precipitate is collected by filtration, washed with cold EtOH (5 ml×2) and dried in vacuum to give 2-(4'-fluorophenyl)-4-(4'-bromophenyl)thiazole as a white fluffy crystaline solid (1.55 g, 93%). mp.158-9° C.

1. temperaturechilled in ice bath
2. filtrationThe precipitate is collected by filtration
3. washwashed with cold EtOH (5 ml×2)
4. customdried in vacuum