Methanol → HCID 22120786, compound

HRID 1274230Notes

Reaction equation

HRID 1274230 reaction equation
C([O:3][C:4](=[O:34])[CH:5]([C:23]1[S:24][C:25]([CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[N:30]2)=[CH:26][CH:27]=1)[NH:6][C:7](=[O:22])[CH:8]([CH2:17][S:18]C(=O)C)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C.CO>C(Cl)(Cl)Cl>[N:29]1([CH2:28][C:25]2[S:24][C:23]([CH:5]([C:4]([OH:34])=[O:3])[NH:6][C:7](=[O:22])[CH:8]([CH2:17][SH:18])[CH2:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:27][CH:26]=2)[CH:33]=[CH:32][N:31]=[N:30]1

Participants

4

Reactant 2

HCID 887MethanolHCID 22120771HCID 22120771, compound

Product 1

HCID 22120786HCID 22120786, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from 2-[5-(1,2,3-triazol-1-ylmethyl)thien-2-yl]-N-[2-(acetylthiomethyl)-4-phenylbutyryl]glycine ethyl ester (Description 57) by the procedure described in Example 24 except that the eluent used was 20% methanol indichloromethane. vmax (CHCl3) 3292, 1731, 1648 and 1602 cm-1. δ (CD3SOCD3) 1.70-1.82 (2H, m), 2.46-2.74 (5H, m), 5.22 (1H, d, J 6.85 Hz), 5.72 (2H, s), 6.85-7.31 (7H, m), 7.68 and 7.72 (1H, two s's), 8.11 and 8.14 (1H, two s's).

Sources & evidence

ORD record
ord-1919549a8ca34b24ad55609ed0b85a86
Source dataset
uspto-grants-2000_12
Patent number
US06156774

Reaction notes

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