HCID 22120930, compound → HCID 22120928, compound

HRID 1274239Notes

Reaction equation

HRID 1274239 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:14][CH2:15][C:16]3[CH:23]4[CH2:24][N:19]([CH2:20][CH2:21][CH2:22]4)[CH2:18][CH:17]=3)=[C:10](Br)[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C1(C)C=CC=CC=1>[C:1]([N:4]1[C:12]2[CH:11]=[C:10]3[C:16]4([CH2:15][O:14][C:9]3=[CH:8][C:7]=2[CH2:6][CH2:5]1)[CH:23]1[CH2:24][N:19]([CH2:20][CH2:21][CH2:22]1)[CH2:18][CH2:17]4)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 22120930HCID 22120930, compound

Product 1

HCID 22120928HCID 22120928, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The title compound was prepared from 1-acetyl-5-(1-azabicyclo[3.3.1]non-3-en-4-yl)methoxy-6-bromo-2,3-dihydro-1H-indole (D9) by a similar procedure to Description 4 using toluene as solvent. The two isomers (2:1 ratio) formed around the spirocyclic junction were separated by column chromatography on silica gel eluting with 0-15% methanol/chloroform.

Sources & evidence

ORD record
ord-e0221adaecfc42b3856477a7b720c91d
Source dataset
uspto-grants-2000_12
Patent number
US06156783

Reaction notes

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