Thioacetamide → HCID 9823301, compound

HRID 1274348Notes

Reaction equation

HRID 1274348 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21](=O)[CH2:22]Br.[C:25]([NH2:28])(=[S:27])[CH3:26]>C(O)C>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[N:28]=[C:25]([CH3:26])[S:27][CH:22]=1

Participants

4

Reactant 2

HCID 2723949ThioacetamideHCID 22120909HCID 22120909, compound

Product 1

HCID 9823301HCID 9823301, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5-amino-4-bromoacetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.1 g) in ethanol (5 ml) was added thioacetamide (0.0375 g). After 1 hour at room temperature the mixture was evaporated and the residue was purified by column chromatography on silica gel (10 g) eluted with dichloromethane. Combination and evaporation of suitable fractions gave the title compound as a white solid, m.p. 226-8° C.

Workup

  1. customAfter 1 hour at room temperature the mixture was evaporated
  2. customthe residue was purified by column chromatography on silica gel (10 g)
  3. washeluted with dichloromethane
  4. customCombination and evaporation of suitable fractions

Sources & evidence

ORD record
ord-5944f50a630e49cb8b3c3d7ffaf90b36
Source dataset
uspto-grants-2000_12
Patent number
US06156782

Reaction notes

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