反应详情

To a solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(furan-3-yl)pyrazole (0.600 g) in tetrahydrofuran (20 ml) was added N-bromosuccinimide (0.288 g). The mixture was left at room temperature for 2 hours and then poured onto a column of silica gel (30 g) and eluted with hexane:dichloromethane (1:1). Combination and evaporation of suitable fractions gave a red oil which was further purified by column chromatography on silica gel (30 g) eluted with hexane:dichloromethane (1:1), then dichloromethane. Combination and evaporation of suitable fractions gave the title compound as a white solid.

1. additionpoured onto a column of silica gel (30 g)
2. washeluted with hexane:dichloromethane (1:1)
3. customCombination and evaporation of suitable fractions
4. customgave a red oil which
5. customwas further purified by column chromatography on silica gel (30 g)
6. washeluted with hexane:dichloromethane (1:1)
7. customCombination and evaporation of suitable fractions