反应详情

To a stirred solution of 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(furan-3-yl)pyrazole (0.19 g) in tetrahydrofuran (5 ml) was added portionwise N-bromosuccinimide (0.093 g). The mixture was left at room temperature for 24 hours and then poured into ether (15 ml) and water (15 ml). The layers were separated and the organic layer was dried (Na2SO4) and evaporated. The residue was purified by column chromatography on silica gel (10 g) eluted with hexane:dichloromethane (1:1). Combination and evaporation of suitable fractions gave the title compound as a white solid, m.p. 111° C.

1. customThe layers were separated
2. dry with materialthe organic layer was dried (Na2SO4)
3. customevaporated
4. customThe residue was purified by column chromatography on silica gel (10 g)
5. washeluted with hexane:dichloromethane (1:1)
6. customCombination and evaporation of suitable fractions