反应详情

To a 300-ml three-necked round flask (equipped with a stirrer tip, a Zimroth condenser, a thermometer and a NaOH trap) were fed 39.9 g (157.2 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 77.7 ml (1,065 mmol) of thionyl chloride, and the contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 45.6 g of a coarse product of an yellow-orange liquid. This acid chloride was used for the next reaction without any further purification.

1. customTo a 300-ml three-necked round flask (equipped with a stirrer tip
2. temperaturethe contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere
3. distillationthe unreacted thionyl chloride was distilled off under reduced pressure