HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Pyrazin-2-yl-1H-pyrimidine-2,4-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,4-Dimethoxy-5-pyrazin-2-yl-pyrimidine | HCID 58994206 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Pyrazin-2-yl-1H-pyrimidine-2,4-dione hydrochloride | HCID 68696929 | — |
Reaction Steps
2,4-Dimethoxy-5-pyrazin-2-yl-pyrimidine (Prep124, 481 mg, 2.19 mmol) was dissolved in 4M HCl in dioxane solution (7 ml). After refluxing the reaction mixture for 1 hour, the solvent was removed under vacuum to give the title compound (quantitative yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-acd790e96df7459bb8e6de5a9519bbe7 |
| Source note | uspto-grants-2010_06 |