Hydrochloric Acid → 5-Pyrazin-2-yl-1H-pyrimidine-2,4-dione hydrochloride

HRID 12744Notes

Reaction equation

HRID 12744 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)=[CH:5][N:4]=1.[ClH:17]>O1CCOCC1>[ClH:17].[N:12]1[CH:13]=[CH:14][N:15]=[CH:16][C:11]=1[C:6]1[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 589942062,4-Dimethoxy-5-pyrazin-2-yl-pyrimidine

Product 1

HCID 686969295-Pyrazin-2-yl-1H-pyrimidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2,4-Dimethoxy-5-pyrazin-2-yl-pyrimidine (Prep124, 481 mg, 2.19 mmol) was dissolved in 4M HCl in dioxane solution (7 ml). After refluxing the reaction mixture for 1 hour, the solvent was removed under vacuum to give the title compound (quantitative yield)

Workup

  1. temperatureAfter refluxing the reaction mixture for 1 hour
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-acd790e96df7459bb8e6de5a9519bbe7
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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