反应详情

4-(7-chloroquinolin-4-yl)butyn-1-ol (1 g) was dissolved in ethanol (25 mL) in a Parr hydrogenation bottle and platinum (IV) oxide [Adams' Catalyst] (100 mg) was added. The Parr bottle was placed on a Parr hydrogenation apparatus and the solution hydrogenated at 50 psi for 2 hours after which time the starting material had been judged to be consumed by TLC. The spent catalyst was removed by filtration through a Celite pad and the pad carefully washed with more ethanol. The combined filtrates were evaporated in vacuo and the residue purified by flash chromatography on silica gel (ethyl acetate; then ethyl acetate:methanol, 95:5) to give the title compound (500 mg).

1. additionwas added
2. customto be consumed by TLC
3. customThe spent catalyst was removed by filtration through a Celite pad
4. washthe pad carefully washed with more ethanol
5. customThe combined filtrates were evaporated in vacuo
6. customthe residue purified by flash chromatography on silica gel (ethyl acetate