反应详情

70 mg (0.32 mmol) of alcohol 46 is dissolved in 5 ml of CH2Cl2, and 6 4A molecular sieve spheres and 66 mg (0.48 mmol, 1.5 equivalents) of 4-methylmorpholine N-oxide (NMO) are added. After 10 minutes of stirring, 6 mg of tetrapropylammonium-perruthenate(VII) (TPAP) (0.016 mmol, 0.05 equivalent) is added and stirred for 4 hours at room temperature. Then, the reaction mixture is concentrated by evaporation in a rotary evaporator and directly purified by column chromatography with pentane:ether=1:1. 60 mg (0.28 mmol) of ethyl ketone 2, corresponding to a yield of 86%, is obtained.

1. stirringstirred for 4 hours at room temperature
2. concentrationThen, the reaction mixture is concentrated by evaporation in a rotary evaporator
3. customdirectly purified by column chromatography with pentane