1-Methylpiperazine → 5[(4-Methyl-1-piperazinyl)-carbonyl]-7-amino-1,4-benzodioxane

HRID 127451Notes

Reaction equation

HRID 127451 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=O)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:12]([C:4]2[C:5]3[O:10][CH2:9][CH2:8][O:7][C:6]=3[CH:11]=[C:2]([NH2:1])[CH:3]=2)=[O:14])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 205447527-Amino-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

Product 1

HCID 205447305[(4-Methyl-1-piperazinyl)-carbonyl]-7-amino-1,4-benzodioxane

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as described in Example 2, the 7-amino-1,4-benzodioxane-5-carboxylic acid was treated with the methanol, and then the obtained carboxylic ester was reacted with N-methyl piperazine. 5[(4-methyl-1-piperazinyl)-carbonyl]-7-amino-1,4-benzodioxane was obtained (M.P.: 170° C.).

Sources & evidence

ORD record
ord-febc288bf0ef40fbaa5e80cb25c7dfb2
Source dataset
uspto-grants-1981_03
Patent number
US04255580

Reaction notes

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