Trifluoroacetic acid → HCID 70096977, compound

HRID 1274567Notes

Reaction equation

HRID 1274567 reaction equation
FC(F)(F)C(O)=O.[CH3:8][N:9]1[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][C:12](=[O:19])[N:11]([C:20]2[CH:21]=[CH:22][C:23]3[S:27][N:26]=[C:25]([C:28]4[CH:33]=[C:32]([O:34][CH:35]([CH3:43])[C:36]([O:38]C(C)(C)C)=[O:37])[CH:31]=[CH:30][C:29]=4[CH3:44])[C:24]=3[CH:45]=2)[C:10]1=[O:46]>C(Cl)Cl>[CH3:8][N:9]1[C:14]([C:15]([F:17])([F:18])[F:16])=[CH:13][C:12](=[O:19])[N:11]([C:20]2[CH:21]=[CH:22][C:23]3[S:27][N:26]=[C:25]([C:28]4[CH:33]=[C:32]([O:34][CH:35]([CH3:43])[C:36]([OH:38])=[O:37])[CH:31]=[CH:30][C:29]=4[CH3:44])[C:24]=3[CH:45]=2)[C:10]1=[O:46]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70100251HCID 70100251, compound

Product 1

HCID 70096977HCID 70096977, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (75 mL) is added to a solution of tert-butyl 2-{{2-{5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1 (2H)-pyrimidinyl]-1,2-benzisothiazol-3-yl}-p-tolyl}oxy}propionate (12.0 g, 21.4 mmol) in methylene chloride. The reaction mixture is stirred at room temperature for 24 hours and concentrated in vacuo to give the title product as a yellow foam which is identified by NMR spectral analyses.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-72e14195c1244170ba5a7f4754f62c56
Source dataset
uspto-grants-2000_12
Patent number
US06156700

Reaction notes

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