HCID 17778539, compound → HCID 17778540, compound

Participants

Reaction Steps

A mixture of 3-[3-(2-hydroxyethyl)-1,2-benzisothiazol-5-yl-1-methyl-6-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione acetate (1.00 g, 2.42 mmol) in 10% hydrochloric acid (250 mL) is refluxed for 35 minutes and filtered through glass wool to remove solids. The resultant filtrate is cooled and extracted with methylene chloride. The combined organic extracts are washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a yellow solid which is identified by NMR spectral analysis.

Provenance & Evidence