HCID 17778539, compound → HCID 17778540, compound

HRID 1274589Notes

Reaction equation

HRID 1274589 reaction equation
C(O)(=O)C.[OH:5][CH2:6][CH2:7][C:8]1[C:12]2[CH:13]=[C:14]([N:17]3[C:22](=[O:23])[CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[N:19]([CH3:28])[C:18]3=[O:29])[CH:15]=[CH:16][C:11]=2[S:10][N:9]=1>Cl>[OH:5][CH2:6][CH2:7][C:8]1[C:12]2[CH:13]=[C:14]([N:17]3[C:22](=[O:23])[CH:21]=[C:20]([C:24]([F:25])([F:27])[F:26])[N:19]([CH3:28])[C:18]3=[O:29])[CH:15]=[CH:16][C:11]=2[S:10][N:9]=1

Participants

3

Reactant 1

HCID 17778539HCID 17778539, compound

Product 1

HCID 17778540HCID 17778540, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 3-[3-(2-hydroxyethyl)-1,2-benzisothiazol-5-yl-1-methyl-6-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione acetate (1.00 g, 2.42 mmol) in 10% hydrochloric acid (250 mL) is refluxed for 35 minutes and filtered through glass wool to remove solids. The resultant filtrate is cooled and extracted with methylene chloride. The combined organic extracts are washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a yellow solid which is identified by NMR spectral analysis.

Workup

  1. temperatureis refluxed for 35 minutes
  2. filtrationfiltered through glass wool
  3. customto remove solids
  4. temperatureThe resultant filtrate is cooled
  5. extractionextracted with methylene chloride
  6. washThe combined organic extracts are washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-dfdbac6257b34bf0aafab8011555c1bb
Source dataset
uspto-grants-2000_12
Patent number
US06156700

Reaction notes

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