Benzylamine → 2-Benzylamino-4-(t-butyl)amino-3,5,6-trifluoropyridine

HRID 1274683Notes

Reaction equation

CN1CCCC1=O.[C:8]([NH:12][C:13]1[C:18]([F:19])=[C:17]([F:20])[N:16]=[C:15](F)[C:14]=1[F:22])([CH3:11])([CH3:10])[CH3:9].[CH2:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>C(Cl)(Cl)Cl>[CH2:23]([NH:30][C:15]1[C:14]([F:22])=[C:13]([NH:12][C:8]([CH3:9])([CH3:10])[CH3:11])[C:18]([F:19])=[C:17]([F:20])[N:16]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

Conditions

Temperature: 115 °C

Procedure

To 10 ml of N-methylpyrrolidone were added 6.8 g of 4-(t-butylamino)-2,3,5,6-tetrafluoropyridine together with 7.2 g of benzylamine, and the mixture was stirred at 115° C. for one day and allowed to cool. After adding 40 ml of chloroform, the mixture was washed three times with 400 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain about 8.0 g of the title compound as a dark green crude oil.

Workup

temperatureto cool
washthe mixture was washed three times with 400 ml of distilled water
dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-1b96f7fba03b4dda9f73d4d02ae8e453
Source dataset: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06156903

Reaction notes

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