Hydrochloric Acid → HCID 22121168, compound

HRID 1274742Notes

Reaction equation

HRID 1274742 reaction equation
C([NH:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[Cl:22])[C:15](=[O:25])[CH:14]([C:26]([O:28]CC)=[O:27])[C:13]2=[O:31])[C:9]([C:32]#[N:33])=[CH:8][C:7]=1[F:34])(C)(C)C.Cl>>[NH2:5][C:6]1[N:11]=[C:10]([N:12]2[C:21]3[C:16](=[CH:17][C:18]([F:24])=[C:19]([F:23])[C:20]=3[Cl:22])[C:15](=[O:25])[CH:14]([C:26]([OH:28])=[O:27])[C:13]2=[O:31])[C:9]([C:32]#[N:33])=[CH:8][C:7]=1[F:34]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22121260HCID 22121260, compound

Product 1

HCID 22121168HCID 22121168, compoundYield 51.6%

Procedure

To 280 mg of ethyl 1-(6-t-butylamino-3-cyano-5-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinolone-3-carboxylate was added 3 ml of 12N hydrochloric acid, and the mixture was heated under reflux for 6 hours and allowed to cool. The solid precipitate was collected by filtration and washed with ethanol and diethylether successively to obtain 120 mg of the title compound as a pale yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureto cool
  4. filtrationThe solid precipitate was collected by filtration
  5. washwashed with ethanol and diethylether successively

Sources & evidence

ORD record
ord-a1c49c58ebbb4981b3f28ee1c8e2c894
Source dataset
uspto-grants-2000_12
Patent number
US06156903

Reaction notes

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