Hydrochloric Acid → 8-Chloro-6,7-difluoro-1-(3,5-difluoro-6-isopropylaminopyridin-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

HRID 1274764Notes

Reaction equation

HRID 1274764 reaction equation
Cl.[Cl:2][C:3]1[C:4]([F:32])=[C:5]([F:31])[CH:6]=[C:7]2[C:12]=1[N:11]([C:13]1[C:18]([F:19])=[CH:17][C:16]([F:20])=[C:15]([NH:21][CH:22]([CH3:24])[CH3:23])[N:14]=1)[CH:10]=[C:9]([C:25]([O:27]CC)=[O:26])[C:8]2=[O:30]>C(O)(=O)C>[Cl:2][C:3]1[C:4]([F:32])=[C:5]([F:31])[CH:6]=[C:7]2[C:12]=1[N:11]([C:13]1[C:18]([F:19])=[CH:17][C:16]([F:20])=[C:15]([NH:21][CH:22]([CH3:24])[CH3:23])[N:14]=1)[CH:10]=[C:9]([C:25]([OH:27])=[O:26])[C:8]2=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22121250Ethyl 8-chloro-6,7-difluoro-1-(3,5-difluoro-6-isopropylamino-pyridine-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product 1

HCID 221212218-Chloro-6,7-difluoro-1-(3,5-difluoro-6-isopropylaminopyridin-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acidYield 94.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 3 ml of the mixed solution of 4N hydrochloric acid and acetic acid (1:1, v/v) was added 300 mg of ethyl 8-chloro-6,7-difluoro-1-(3,5-difluoro-6-isopropylamino-pyridine-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux for 19 hours with stirring. The precipitate was collected by filtration, washed with ethanol and diisopropylether successively to obtain 265 mg of the title compound as a yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 19 hours
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with ethanol and diisopropylether successively

Sources & evidence

ORD record
ord-2f5c0716175748c2be2887f0ecfc9a5c
Source dataset
uspto-grants-2000_12
Patent number
US06156903

Reaction notes

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