HCID 20287108, compound → HCID 20287163, compound

HRID 127477Notes

Reaction equation

HRID 127477 reaction equation
[ClH:1].[OH:2][CH:3]([C:19]1[CH:20]=[CH:21][C:22]([O:29][CH3:30])=[C:23]([CH:28]=1)[C:24](OC)=[O:25])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[CH2:7][CH2:6]1.Cl.OC(C1C=CC(OC)=C(C=1)C(OC)=O)C[N:35]1CCN(C2C=CC=CC=2C)CC1.COC(=O)C1C=C(C(O)CN2CCN(C3C=CC=CC=3)CC2)C=CC=1OC>>[ClH:1].[OH:2][CH:3]([C:19]1[CH:20]=[CH:21][C:22]([O:29][CH3:30])=[C:23]([CH:28]=1)[C:24]([NH2:35])=[O:25])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[CH2:7][CH2:6]1

Participants

4

Reactant 3

HCID 20287108HCID 20287108, compoundHCID 20287142HCID 20287142, compoundHCID 20287156HCID 20287156, compound

Product 1

HCID 20287163HCID 20287163, compound

Procedure

Following essentially the same procedure but substituting methyl 5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride and methyl 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride for the methyl-5-[1-hydroxy-2-(4-phenyl-1-piperazinyl)ethyl]-2-methoxybenzoate above results in the preparation of 5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-methoxybenzamide hydrochloride, having a m.pt. of 247°-8° C. (dec.) and 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxybenzamide hydrochloride, having a m.pt. of 214°-6° C. (dec.), respectively.

Sources & evidence

ORD record
ord-42c0d3feb6af41389488130e6255a5fa
Source dataset
uspto-grants-1981_03
Patent number
US04255575

Reaction notes

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