HCID 20287108, compound → HCID 20287163, compound

Participants

Reaction Steps

Following essentially the same procedure but substituting methyl 5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride and methyl 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxybenzoate hydrochloride for the methyl-5-[1-hydroxy-2-(4-phenyl-1-piperazinyl)ethyl]-2-methoxybenzoate above results in the preparation of 5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-2-methoxybenzamide hydrochloride, having a m.pt. of 247°-8° C. (dec.) and 5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-2-methoxybenzamide hydrochloride, having a m.pt. of 214°-6° C. (dec.), respectively.

Provenance & Evidence