HCID 54380061, compound → 5-Amino-1-(6-amino-3,5-difluoropyridine-2-yl)-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Participants

Reaction Steps

To 0.99 g of ethyl 5-amino-6,7-difluoro-1-(3,5-difluoro-6-p-methoxybenzylaminopyridine-2-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was added 10 ml of 12N hydrochloric acid, and the mixture was heated under reflux for 10 hours. The reaction solution was allowed to cool, and the solid content was collected by filtration. The solid content was washed with ethanol, and then, with diethylether to obtain 880 mg of the title compound as a yellow powder.

Provenance & Evidence