HCID 54380061, compound → HCID 22121237, compound

HRID 1274778Notes

Reaction equation

HRID 1274778 reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([CH3:14])=[C:8]2[C:3]=1[C:4](=[O:38])[C:5]([C:33]([O:35]CC)=[O:34])=[CH:6][N:7]2[C:15]1[C:20]([F:21])=[CH:19][C:18]([F:22])=[C:17]([NH:23]CC2C=CC(OC)=CC=2)[N:16]=1>Cl>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([CH3:14])=[C:8]2[C:3]=1[C:4](=[O:38])[C:5]([C:33]([OH:35])=[O:34])=[CH:6][N:7]2[C:15]1[C:20]([F:21])=[CH:19][C:18]([F:22])=[C:17]([NH2:23])[N:16]=1

Participants

3

Reactant 1

HCID 54380061HCID 54380061, compound

Product 1

HCID 22121237HCID 22121237, compoundYield 123.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 0.99 g of ethyl 5-amino-6,7-difluoro-1-(3,5-difluoro-6-p-methoxybenzylaminopyridine-2-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate was added 10 ml of 12N hydrochloric acid, and the mixture was heated under reflux for 10 hours. The reaction solution was allowed to cool, and the solid content was collected by filtration. The solid content was washed with ethanol, and then, with diethylether to obtain 880 mg of the title compound as a yellow powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 10 hours
  3. temperatureto cool
  4. filtrationthe solid content was collected by filtration
  5. washThe solid content was washed with ethanol

Sources & evidence

ORD record
ord-2b73009026bd47eba3b83249bb837123
Source dataset
uspto-grants-2000_12
Patent number
US06156903

Reaction notes

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