Glycolic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

Participants

Reaction Conditions

Reaction Steps

A PFA-made cylinder was charged with 35.72 g (0.248 mol) of recrystallized L-(-)-lactide and 162.4 g (1.4 mol) of glycolide, and 17.0 ml of bis-2-methoxyethyl phthalate, 0.20 ml of a toluene solution of tin octanoate at a molar concentration of 0.33 and 0.0626 g of glycolic acid were added. After toluene was removed under high vacuum of 0.1 mmHg, and purging with nitrogen was conducted twice, the contents were heated at 180° C. for 40 minutes with stirring. The heating was further continued for 4 hours and 20 minutes to conduct polymerization. The resultant polymer was ground into fine particles having a particle size of about 3 mm or smaller. The fine particles were dried at about 25° C. for 48 hours under reduced pressure of about 0.1 kPa, thereby obtaining a glycolic acid/lactic acid copolymer [Polymer (P-C2)]. The same process was conducted repeatedly to prepare a necessary amount of Polymer (P-C2).

Provenance & Evidence