Glycolic Acid → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)
Reaction equation
[CH3:1][C@@H:2]1[O:9]C(=O)[C@H](C)[O:5][C:3]1=[O:4].C1OC(=O)COC1=O.C([O-])(=O)CCCCCCC.[Sn+4].C([O-])(=O)CCCCCCC.C([O-])(=O)CCCCCCC.C([O-])(=O)CCCCCCC.C(O)(=O)CO>C1(C)C=CC=CC=1>[C:3]([OH:5])(=[O:4])[CH2:2][OH:9].[C:3]([OH:5])(=[O:4])[CH:2]([CH3:1])[OH:9]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 180 °C
Procedure
A PFA-made cylinder was charged with 35.72 g (0.248 mol) of recrystallized L-(-)-lactide and 162.4 g (1.4 mol) of glycolide, and 17.0 ml of bis-2-methoxyethyl phthalate, 0.20 ml of a toluene solution of tin octanoate at a molar concentration of 0.33 and 0.0626 g of glycolic acid were added. After toluene was removed under high vacuum of 0.1 mmHg, and purging with nitrogen was conducted twice, the contents were heated at 180° C. for 40 minutes with stirring. The heating was further continued for 4 hours and 20 minutes to conduct polymerization. The resultant polymer was ground into fine particles having a particle size of about 3 mm or smaller. The fine particles were dried at about 25° C. for 48 hours under reduced pressure of about 0.1 kPa, thereby obtaining a glycolic acid/lactic acid copolymer [Polymer (P-C2)]. The same process was conducted repeatedly to prepare a necessary amount of Polymer (P-C2).
Workup
- additionwere added
- customAfter toluene was removed under high vacuum of 0.1 mmHg
- custompurging with nitrogen
- custompolymerization
- customThe fine particles were dried at about 25° C. for 48 hours under reduced pressure of about 0.1 kPa
Sources & evidence
- ORD record
- ord-2139a5c674ad4bca9690416f4bbabdfa
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06159416
Reaction notes
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