Hydrochloric Acid → HCID 86756096, compound

HRID 1274811Notes

Reaction equation

HRID 1274811 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=[C:5]([C:20]([NH:22][NH2:23])=[O:21])[CH:4]=1.[CH:24](=O)[CH2:25][CH3:26].C(OCC)C.Cl>C(Cl)(Cl)Cl>[CH:24](=[N:23][NH:22][C:20](=[O:21])[C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:11]=2)[N:6]=1)[CH2:25][CH3:26]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 527PropanalHCID 3283Diethyl EtherHCID 70268884HCID 70268884, compound

Product 1

HCID 86756096HCID 86756096, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid hydrazide (0.5 g, 0.0015 mol) was mixed with propionaldehyde (0.27 g, 0.0015×3.1 mol), and further with a mixed solution of diethyl ether and chloroform and a small amount of concentrated hydrochloric acid. The resultant solution was heated and refluxed for about 8 hours. The obtained reaction solution was concentrated and then purified by silica gel column chromatography (eluting solution: ethyl acetate/hexane), thereby obtaining an aimed product.

Workup

  1. temperaturerefluxed for about 8 hours
  2. customThe obtained reaction solution
  3. concentrationwas concentrated
  4. custompurified by silica gel column chromatography (eluting solution: ethyl acetate/hexane)

Sources & evidence

ORD record
ord-36be1bc8ae8949cfa93f41796271bc7a
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

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