Ethyl Acetate → HCID 70268884, compound

HRID 1274822Notes

Reaction equation

HRID 1274822 reaction equation
C([N:8](CC1C=CC=CC=1)[NH:9][C:10](=[O:30])[C:11]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[N:12]=1)C1C=CC=CC=1.C(OCC)(=O)C.[H][H]>[Pd].CO>[CH3:18][O:17][C:15]1[CH:14]=[C:13]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:27])([F:28])[F:29])[CH:21]=2)[N:12]=[C:11]([C:10]([NH:9][NH2:8])=[O:30])[CH:16]=1

Participants

6

Reactant 3

HCID 8857Ethyl AcetateHCID 131722205HCID 131722205, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70268884HCID 70268884, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-methoxy-6-[3-(trifluoromethyl)phenoxy] picolinic acid, N',N'-dibenzyl hydrazide (7.38 g, 0.0145 mol) was mixed with a mixed solution of ethyl acetate (about 50 ml) and methanol (about 50 ml), and further with 10% palladium/carbon (1.0 g, 0.0145×0.065 mol) in a hydrogen atmosphere. The resultant mixture was stirred at a temperature of 50 to 60° C. for about 5 hours. The obtained reaction solution was filtered and concentrated, thereby obtaining an aimed product.

Workup

  1. customThe obtained reaction solution
  2. filtrationwas filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d91692e0ab454d539ef0b5ef36628b97
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

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