Acetic Acid → HCID 21249822, compound

HRID 1274837Notes

Reaction equation

HRID 1274837 reaction equation
C(C1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[N:4]=1)#N.[C:21]([OH:24])(=[O:23])[CH3:22]>Cl>[CH3:9][C:7]1[CH:6]=[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:12]=2)[N:4]=[C:22]([C:21]([OH:24])=[O:23])[CH:8]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 212498314-Methyl-6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarbonitrile

Product 1

HCID 21249822HCID 21249822, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-cyano-4-methyl-6-[3-(trifluoromethyl)phenoxy] pyridine (2.055 g, 0.0074 mol) was heated and stirred in 10 ml of concentrated hydrochloric acid and 6 ml of acetic acid at 110° C. for 5 hours. Thereafter, the obtained reaction solution was concentrated under reduced pressure. The obtained residues were mixed with water. The precipitated solids were filtered out, washed with water and then dried, thereby obtaining an aimed product.

Workup

  1. customThereafter, the obtained reaction solution
  2. concentrationwas concentrated under reduced pressure
  3. additionThe obtained residues were mixed with water
  4. filtrationThe precipitated solids were filtered out
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-dec745e2c9aa4f8487e1b9ff5a94584e
Source dataset
uspto-grants-2000_12
Patent number
US06159901

Reaction notes

Loading…