1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine → HCID 9846831, compound

HRID 1274844Notes

Reaction equation

HRID 1274844 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])[CH2:6][CH2:5]1.C(O[CH:21]=[N:22][C:23]1[S:24][C:25]([C:34](=[O:38])[N:35]([CH3:37])[CH3:36])=[C:26]([CH3:33])[C:27]=1[C:28](OCC)=[O:29])C>C(O)C>[CH3:33][C:26]1[C:27]2[C:28](=[O:29])[N:1]([CH2:2][CH2:3][N:4]3[CH2:5][CH2:6][N:7]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=4[O:16][CH3:17])[CH2:8][CH2:9]3)[CH:21]=[N:22][C:23]=2[S:24][C:25]=1[C:34](=[O:38])[N:35]([CH3:37])[CH3:36]

Participants

4

Reactant 2

HCID 103991861-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazineHCID 54432745HCID 54432745, compound

Product 1

HCID 9846831HCID 9846831, compoundYield 62.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.9 g (8.0 mM [sic]) of 1-(2-aminoethyl)-4-(2-methoxyphenyl)-piperazine were added to 2.4 g (7.8 mM [sic]) of 2-ethoxymethyleneamino-3-carboethoxy-4-methyl-5-dimethylcarbamoyl thiophene in 30 ml of ethanol and refluxed for 2 h. The product crystallized out after standing overnight and was filtered off with suction and washed with a little ethanol. 2.2 g (62%) of product were isolated with melting point 188-190° C.

Workup

  1. temperaturerefluxed for 2 h
  2. customThe product crystallized out
  3. filtrationwas filtered off with suction
  4. washwashed with a little ethanol

Sources & evidence

ORD record
ord-895a96f61303405691a65138bd84ba66
Source dataset
uspto-grants-2000_12
Patent number
US06159962

Reaction notes

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