Hydrochloric Acid → HCID 22118263, compound

HRID 1274869Notes

Reaction equation

HRID 1274869 reaction equation
C([Zn][CH2:4][CH3:5])C.[CH3:6][C:7]1[O:12][CH2:11][N:10]([C:13]([CH3:20])([CH:15]([OH:19])[CH2:16][CH:17]=[CH2:18])[CH3:14])[C:9](=[O:21])[C:8]=1C1C=CC=CC=1.I[CH:29](I)[CH3:30].Cl.[CH3:33][CH2:34][CH2:35][CH2:36]CC>ClCCl>[CH3:6][C:7]1[O:12][CH2:11][N:10]([C:13]([CH3:14])([CH:15]([OH:19])[CH2:16][CH:17]2[CH2:18][CH:29]2[CH3:30])[CH3:20])[C:9](=[O:21])[C:8]=1[C:5]1[CH:4]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 68980DiiodoethaneHCID 22118283HCID 22118283, compoundHCID 178418750HCID 178418750, compound

Product 1

HCID 22118263HCID 22118263, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
45 °C

Procedure

A solution of diethyl zinc in n-hexane(1M, 12 ml) was added to a solution of 2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methyl-hex-5-en-3-ol (1.6 g) in dichloromethane at 20° C. 1,1-Diiodoethane (3.5 g) was added and the solution warmed to 45° C. for 3 hours. Hydrochloric acid (1N) was added and the organic layer washed (brine), dried (magnesium sulphate) and evaporated. Purification by silica gel column chromatography eluting with n-hexane/ethyl acetate (3:1) gave 2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methyl-4-(2-methylcyclopropyl)butan-3-ol (0.55 g), NMR:1.05-1.75(4H), 1.01(d,3H), 1.36(s,3H), 1.52(s,3H), 1.4-1.5(2H), 1.89(s,3H), 3.70(1H), 4.59(1H), 5.10(d,1H), 5.24(d,1H),7.23-7.40(5H). Powdered molecular sieve (4 A, 3.2 g) and pyridinium chlorochromate (0.8 g) were added to a stirred solution of the above compound in dichloromethane at 20° C. After 3 hours, ether was added and the mixture filtered. The filtrate was evaporated and the residue purified by silica gel column chromatography eluting with n-hexane/ethyl acetate (3:1) to give 2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methyl-4-(2-methylcyclopropyl)butan-3-one (Compound 1074, 0.47 g), NMR: 0.20-0.30(2H), 0.42-0.52(1H), 0.68-0.78(1H), 1.03(d,3H), 1.42(s,6H), 1.93(s,3H), 2.43(d,2H), 5.26(s,2H), 7.20-7.40(5H).

Workup

  1. washthe organic layer washed (brine)
  2. dry with materialdried (magnesium sulphate)
  3. customevaporated
  4. customPurification by silica gel column chromatography
  5. washeluting with n-hexane/ethyl acetate (3:1)

Sources & evidence

ORD record
ord-bb177a1235784c9a96b0cb94fbc7e05e
Source dataset
uspto-grants-2000_12
Patent number
US06159902

Reaction notes

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