Hydrochloric Acid → HCID 21699329, compound

HRID 1274889Notes

Reaction equation

HRID 1274889 reaction equation
[Cl:1][CH2:2]/[C:3](/[NH:12][C:13]([NH2:15])=[O:14])=[C:4](\[C:10]#[N:11])/[C:5](OCC)=[O:6].Cl>[OH-].[Na+]>[C:10]([C:4]1[C:5](=[O:6])[NH:15][C:13](=[O:14])[NH:12][C:3]=1[CH2:2][Cl:1])#[N:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86752466HCID 86752466, compound

Product 1

HCID 21699329HCID 21699329, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Dissolved in 17 ml of a 2 N aqueous solution of sodium hydroxide were 3.88 g of the ethyl 4-chloro-2-cyano-ureidocrotonate (22) obtained in Referential Example 5. The resulting mixture was stirred at room temperature for 1 hour and under ice cooling, was neutralized with 2 N hydrochloric acid. A crystallized matter was collected by filtration, whereby 1.16.g of the title compound were obtained (yield: 37%).

Workup

  1. customobtained in Referential Example 5
  2. filtrationA crystallized matter was collected by filtration, whereby 1.16.g of the title compound
  3. customwere obtained (yield: 37%)

Sources & evidence

ORD record
ord-1987d31e4bee4146a9be9c4d9f60a1a5
Source dataset
uspto-grants-2000_12
Patent number
US06159969

Reaction notes

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