1-(1H-Imidazol-1-yl)ethanone → HCID 17890407, compound

HRID 1274893Notes

Reaction equation

HRID 1274893 reaction equation
C([N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1)(=O)C.[Cl:9][C:10]1[C:11](=[O:19])[NH:12][C:13](=[O:18])[NH:14][C:15]=1[CH2:16]Cl>CO>[ClH:9].[Cl:9][C:10]1[C:11](=[O:19])[NH:12][C:13](=[O:18])[NH:14][C:15]=1[CH2:16][C:5]1[NH:4][CH:8]=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 41710565-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product 1

HCID 17890407HCID 17890407, compoundYield 128.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4.3 g of N-acetylimidazole in methanol (100 ml), 5.0 g of 5-chloro-6-chloromethyluracil were added, followed by heating for 2 days under reflux. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration and then washed with a 10% solution of hydrochloric acid in methanol, whereby 4.32 g of the title compound were obtained (yield: 64%).

Workup

  1. temperatureby heating for 2 days
  2. temperatureunder reflux
  3. temperatureto cool down
  4. filtrationa crystallized matter was collected by filtration
  5. washwashed with a 10% solution of hydrochloric acid in methanol

Sources & evidence

ORD record
ord-e5e96ca9c3194d75a9919c940f539fc5
Source dataset
uspto-grants-2000_12
Patent number
US06159969

Reaction notes

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