HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1H-Imidazol-1-yl)ethanone → HCID 17890407, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1H-Imidazol-1-yl)ethanone | HCID 17174 | — |
| Reactant | 5-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 4171056 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 17890407 | HCID 17890407 | 128.1% |
Reaction Steps
To a solution of 4.3 g of N-acetylimidazole in methanol (100 ml), 5.0 g of 5-chloro-6-chloromethyluracil were added, followed by heating for 2 days under reflux. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration and then washed with a 10% solution of hydrochloric acid in methanol, whereby 4.32 g of the title compound were obtained (yield: 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06159969 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-e5e96ca9c3194d75a9919c940f539fc5 |
| Source note | uspto-grants-2000_12 |