Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 5-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 4171056 | — |
| Product | HCID 15908416 | HCID 15908416 | 61% |
Reaction Steps
A suspension of 0.50 g of 5-chloro-6-chloromethyluracil and 0.22 g of methyl isothiocyanate in N,N-dimethylformamide (3 ml) was heated at 70° C. for 4 hours under stirring. Water (50 ml) was added to the reaction mixture. A crystallized matter was collected by filtration and then washed with water and methanol, whereby 435 mg of the title compound were obtained (yield: 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06159969 |
|---|
| Source dataset | uspto-grants-2000_12 |
|---|
| ORD ID | ord-a1adeda0a6f74844b353d040a3dfd2e2 |
|---|
| Source note | uspto-grants-2000_12 |
|---|
