Water → HCID 15908416, compound

HRID 1274898Notes

Reaction equation

HRID 1274898 reaction equation
[Cl:1][C:2]1[C:3](=[O:11])[NH:4][C:5](=[O:10])[NH:6][C:7]=1[CH2:8]Cl.[CH3:12][N:13]=[C:14]=[S:15].O.C[N:18](C)C=O>>[CH3:12][NH:13][C:14]([NH:18][CH2:8][C:7]1[NH:6][C:5](=[O:10])[NH:4][C:3](=[O:11])[C:2]=1[Cl:1])=[S:15]

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 11167Methyl isothiocyanateHCID 41710565-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product 1

HCID 15908416HCID 15908416, compoundYield 61%

Conditions

Temperature
70 °C

Procedure

A suspension of 0.50 g of 5-chloro-6-chloromethyluracil and 0.22 g of methyl isothiocyanate in N,N-dimethylformamide (3 ml) was heated at 70° C. for 4 hours under stirring. Water (50 ml) was added to the reaction mixture. A crystallized matter was collected by filtration and then washed with water and methanol, whereby 435 mg of the title compound were obtained (yield: 61%).

Workup

  1. filtrationA crystallized matter was collected by filtration
  2. washwashed with water and methanol

Sources & evidence

ORD record
ord-a1adeda0a6f74844b353d040a3dfd2e2
Source dataset
uspto-grants-2000_12
Patent number
US06159969

Reaction notes

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