2,6-Dichloroaniline → HCID 20284762, compound

HRID 127491Notes

Reaction equation

HRID 127491 reaction equation
C([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=O)C.[C:10]([O-:14])(=O)[CH:11]=[O:12].[Cl:15][C:16]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:17]=1[NH2:18]>CO>[Cl:15][C:16]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:17]=1[N:18]1[C:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C:8]=2[C:10](=[O:14])[C:11]1=[O:12]

Participants

4

Reactant 2

HCID 118462,6-DichloroanilineHCID 86737589HCID 86737589, compound

Product 1

HCID 20284762HCID 20284762, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 65 g (0.33 mols) of ethyl 2-cyclohexanone-glyoxylate and 135 g (0.83 mols) of 2,6-dichloroaniline in 150 ml of methanol is refluxed for 30 hours. After this period, there is introduced steam into the reaction vessel, thus removing the excess 2,6-dichloroaniline. The residue of the steam distillation is removed by filtration and recrystallized from methanol.

Workup

  1. waitAfter this period
  2. additionthere is introduced steam into the reaction vessel
  3. customthus removing the excess 2,6-dichloroaniline
  4. distillationThe residue of the steam distillation
  5. customis removed by filtration
  6. customrecrystallized from methanol

Sources & evidence

ORD record
ord-e1f4212d87be47f59e41d91671b3bbaf
Source dataset
uspto-grants-1981_03
Patent number
US04256639

Reaction notes

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